Abstract: This paper reviewed the development of control technology in domestic and foreign launch vehicle (LV), and based on which, the key technologies of control system for Chinese heavy-lift launch vehicles were proposed. A dynamic on-line trajectory planning technique was discussed to meet the demand of guidance control under complex constraints, and model based identification and adaptive control technology was suggested to deal with the control problems caused by model uncertainty and disturbance, and an integrated avionics system based on high speed communication was put forward for module integration and distributed control, and FBG based real time flight control was also discussed. Moreover, other key technologies, such as wireless interconnection, wireless power transfer, and temporal and spatial partitioning operating system, are both briefly introduced for the application in control systems. These studies will lead to breakthroughs in autonomous flight control in LV, and provide technical support for more long-term deep space explorations.